Overview
| Imported or not | no | Product Name | 5-Amino Levulinic acid hydrochloride |
| CAS | 5451-09-2 | purpose | Biochemical research |
| Appearance traits | White or light yellow powder | specifications | reagent grade |
| Chemical name | 5-Amino Levulinic acid hydrochloride | brand | Chuangyuan Chemical |
| Is it a hazardous chemical | no | Product level | Industrial grade |
| content | ninety-nine | producing area | Jiangsu |
Product Details
5-Amino Levulinic acid hydrochloride
Chinese name: 5-Amino Levulinic acid hydrochloride
English name: 5-Aminolevulinic acid hydrochloride
Chinese alias: 5-Aminolevoronic acid hydrochloride; Β- Amino Levulinic acid hydrochloride; Hydrochloric acid -5-aminofructose acid; Hydrochloric acid -5-aminolevoronic acid; 5-Aminolevoronate; 5-aminoketone valeric acid; DELTA amino Levulinic acid hydrochloride; Aminoaldehydes and aminoketones valeric acid; 5-Aminoacetic acid propionic acid hydrochloride
CASNo. 5451-09-2
Molecular formula: C5H9NO3HCl; C5H10ClNO3
Molecular weight: 167.59
Character: White or slightly yellow powder. It has hygroscopicity. Sensitive to light. Soluble in water and ethanol, very slightly soluble in ethyl acetate. Melting point 144~147 ℃ (decomposition). Maximum absorption wavelength (in water) 266.5nm（ ε 23.0). Irritating.
Usage: Used as a substrate for 5-aminolevoronic acid dehydrogenase, for biochemical research.
5-Amino Levulinic acid
one5-ALA, as a new type of photoactivated pesticide with high environmental compatibility and selectivity, is widely used in the agricultural field.
(1) Plant growth regulators
Recent studies have shown that 5-ALA has the following functions: regulating the synthesis of chlorophyll; Improve the stability of chlorophyll and Photosystem ⅱ; Improving photosynthetic efficiency and promoting photosynthesis; Promote plant tissue differentiation, inhibit respiration in the dark, expand stomata, and other basic physiological activities. Therefore, it is not only a biological Metabolic intermediate, but also involved in the regulation process of plant growth and development. It has physiological activity similar to Plant hormone and can be used as a plant growth regulator in agricultural production.
(2) Green herbicide
The herbicide produced by 5-ALA can kill weeds of Dicotyledon, but is harmless to grains, wheat, barley and other crops that belong to Monocotyledon, and has selective weeding effect.
There are two principles of its action: the first one inhibits the gene expression of GluTR, prevents the synthesis of 5-ALA, and ultimately leads to plant death due to the lack of 5-ALA. The synthesis of 5-ALA in mammals does not occur through the C5 pathway, so the use of such herbicides will not have adverse effects on the human body. The second type can relieve the regulatory mechanism of 5-ALA synthesis and promote a large amount of 5-ALA synthesis. For example, aciferorferr metal can inhibit the synthesis of heme in plants, resulting in a large accumulation of 5-ALA and porphyrin compounds, inducing peroxidation reactions under luminescence. However, due to the high market price of 5-ALA and the high concentration and cost required for its use as a herbicide, it is currently difficult to directly apply it.
(3) Insecticides
It can cause the imbalance of biochemical metabolism in the body of a variety of pests, such as houseflies and cockroaches, so as to make the pests spasm and even die. It has also been studied that the porphyrin insecticide with 5-ALA as the main component acts on the Chinese rice locust in Jinyuan District, Taiyuan. Within 7 days, all the males in the treatment group die, while about half of the males in the control group die. There is no significant difference in the number of female deaths at low concentrations. The principle is that under the activation of 5-ALA, reactive oxygen species can be produced, which can convert sunlight into radiation insecticides through the process of plant photosynthesis or trigger the cytochemical synthesis of pests for pest control. This study indicates that it is a pollution-free natural substance with biodegradability and does not cause pest resistance. A new type of green insecticide can be developed.
2. In medicine, 5-ALA, as a new photodynamic drug, is not only used for the treatment of local or systemic skin cancer, but also for the diagnosis of bladder cancer cancer, digestive tract cancer, lung cancer, etc.
3. 5-ALA is also an important intermediate in organic synthesis. Due to its extensive and safe effects, as well as natural pollution-free properties, it has attracted the attention of scholars and industry both domestically and internationally, and has broad application prospects and market development prospects.
Foreign research is mainly concentrated in a few countries such as Japan, the United States, and China (QQ 1914068818 professional production), mainly using chemical methods andSynthesis of 5-ALA by Microbial Fermentation. The research on chemical synthesis methods began in the 1950s and was most active in the 1990s. Researchers have successively studied Hippuric acid and succinic acid（It is an important intermediate product of tetracarboxylic acid in the Citric acid cycle. It is also the degradation product of some amino acids, tetra Carbon compounds, also known as succinic acid C4H6O4）, tetrahydrofurfuramine, Levulinic acid, etc.
Microorganism producing 5-amino Levulinic acid
C4Route: Erythrocytobacteria, Rhodopseudomonas mirabilis
C5Route: Escherichia coli Archaea